Endocrine Abstracts

Introduction: Despite high levels of sunshine, maternal hypovitaminosis D during pregnancy is prevalent in the Mediterranean region, consisting a paradox. The aim of the study was to systematically review trials that investigated vitamin D concentrations during pregnancy in this region, in order to determine predictors of hypovitaminosis D and explain the paradox.Methods: After applying inclusion/exclusion criteria, 15 studies were entered into the syste...

Background: Primary thyroid lymphoma (PTL) is a rare thyroid malignancy. Nevertheless, it frequently presents diagnostic and therapeutic challenges. We describe two patients with PTL with different clinical presentation/clinical picture and outcome.Patients and methods: Two female patients underwent total thyroidectomy, the first, a 67-year-old female patient, because of nodular goitre and the second, a 79-year-old female patient, because of a large, pai...

Introduction: Prenatal and perinatal food manipulation might be related with bone quality in offspring of Wistar rats. This study aimed to assess the impact of different dietary patterns provided before delivery to the mothers on the skeletal characteristics of newborn rats and the levels of insulin.Materials and methods: We randomized 67 timed-pregnant rats into control diet (CD), high-fat (FD) and food-restricted (FR) on the 12th day of gestation. The ...

Introduction: Recent evidence recognized the value of Retinol-Binding Protein (RBP4), as potential biomarker of cardiovascular and cerebrovascular pathology. The possible association between RBP4 and functional vascular disease remains unexplored, while recent data in postmenopausal populations suggested lack of association between RBP4 and subclinical atherosclerosis. We evaluated the possible link between RBP4 and menopause-specific cardiovascular risk factors, in a sample o...

Introduction: Metabolic syndrome and cardiovascular disease (CVD) are well-known long-term implications of the menopausal transition. Lifestyle practices like exercise could potentially act protective with regards to future cardiovascular risk at midlife. We aimed to assess the impact of physical activity on the development of subclinical CVD in postmenopausal women, adjusting for the effect of underlying obesity.Methods: This cross-sectional study from ...

Introduction: In 2017 the term ‘Atypical adenoma’ was removed from the WHO classification, and ‘High-risk adenomas’ was introduced as a term to classify those with rapid growth, radiological invasion, and a high Ki-67 proliferation index. In this retrospective cohort study we have sought to identify the clinical and histological characteristics which are associated with worse outcomes.Methods: Data: We created a dataset of 1793 pa...

Introduction: Differences in the prevalence and prognosis of cardiovascular disease have been linked with gender specific risk factors as well as the differential impact of sex hormones. Moreover, specific genetic polymorphisms may increase further the risk of cardiovascular disease development. Polymorphisms of genes encoding the NADPH/NADPH oxidase system and the endothelial nitric oxide synthase (eNOS) have been associated with atherosclerosis in the general population, but...

Introduction: The prevalence of cardiovascular disease in reproductively active women has received limited attention. Recent data indicated possible adverse effect of non-typical obstetrical risk factors with regards to cardiovascular function. We aimed to evaluate the potential association between anti-mullerian hormone (AMH), a known marker of ovarian reserve, with subclinical atherosclerosis in young premenopausal women.Methods: This was a cross-secti...

Introduction: The aim of this study was to investigate the association between the genetic background of coagulation factors and the presence of oligo- or amenorrhea in adolescent girls diagnosed with anorexia nervosa compared with controls.Patients and Methods: A total of 40 adolescent girls diagnosed with anorexia nervosa aged 14–17 years, as well as 10 age-matched girls, were included in the study. We recorded anthropometric parameters and calcu...

Introduction: Thyroid dysfunction, whether overt or subclinical, has a significant effect on the cardiovascular system. On the other hand, fluctuation of thyroid hormones within the normal range has been associated with long-term health risks, and might have an impact on the vasculature. This study assessed the effect of thyroid hormones on surrogate markers of arterial structure and function in a sample of euthyroid postmenopausal women.Methods: This cr...